Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:21

Article

Dutta, Rinku¹  Scott, Michael D.¹  Haldar, Manas K.¹  Ganguly, Bratati²  Srivastava, D. K.²  Friesner, Daniel L.³  Mallik, Sanku¹ 

[1] N Dakota State Univ, Dept Pharmaceut Sci, Fargo, ND 58102 USA

[2] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58102 USA

[3] N Dakota State Univ, Dept Pharm Practice, Fargo, ND 58102 USA

关键词: Polymers;    Matrix metalloproteinases;    Enzymes;    Selective interactions;    Fluorescence spectroscopy;   

DOI  :  10.1016/j.bmcl.2011.02.020

来源: Elsevier

【 摘 要 】

Matrix metalloproteinases (MMPs) are overexpressed in various pathological conditions, including cancers. Although these isozymes have similar active sites, the patterns of exposed amino acids on their surfaces are different. Herein, we report the synthesis and molecular interactions of two water soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free