New small molecule inhibitors of hepatitis C virus

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:19

Article

Wei, Wanguo^2,3  Cai, Cuifang^2,3  Kota, Smitha¹  Takahashi, Virginia¹  Ni, Feng^2,3  Strosberg, A. Donny¹  Snyder, John K.^2,3 

[1] Scripps Res Inst, Dept Infectol, Jupiter, FL 33458 USA

[2] Boston Univ, Dept Chem, Boston, MA 02215 USA

[3] Boston Univ, Ctr Chem Methodol Lib Dev CMLD BU, Boston, MA 02215 USA

关键词: Hepatitis C virus;    Core protein;    Inverse electron demand Diels-Alder reaction;    Indoline;    Protein-protein interaction;   

DOI  :  10.1016/j.bmcl.2009.10.070

来源: Elsevier

【 摘 要 】

New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free