Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:28

Article

Fujita, Hiroto¹  Inoue, Yusuke¹  Kuwahara, Masayasu¹ 

[1] Gunma Univ, Grad Sch Sci & Technol, 1-5-1 Tenjin Cho, Kiryu, Gunma 3768515, Japan

关键词: Fibrin;    Fibrinogen;    Modified DNA aptamer;    Thrombin;    Selective entrapment;   

DOI  :  10.1016/j.bmcl.2017.11.022

来源: Elsevier

【 摘 要 】

We found for the first time that a thrombin-binding DNA aptamer (TBA) is selectively entrapped in fibrin gels during the gel growth reaction catalyzed by thrombin. Furthermore, using this phenomenon, we successfully demonstrated multiple incorporation of amphiphilic aliphatic groups into fibrin gels via chemically modified TBA. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free