Macrocyclic chelator assembled RGD multimers for tumor targeting

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:21

Article

Zhang, Xiaofen^1,2  Liu, Hongguang¹  Miao, Zheng¹  Kimura, Richard¹  Fan, Feiyue²  Cheng, Zhen¹ 

[1] Stanford Univ, Med Ctr, Dept Radiol, MIPS, Stanford, CA 94305 USA

[2] Tsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, Inst Radiat Med, Tianjin 300192, Peoples R China

关键词: Molecular imaging;    PET;    Integrin;    Multivalency;    RGD peptide;   

DOI  :  10.1016/j.bmcl.2011.03.110

来源: Elsevier

【 摘 要 】

Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free