A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:26

Article

Wang, Ke^1,2  Friscourt, Frederic^3,4  Dai, Chaofeng^1,2  Wang, Lifang^1,2  Zheng, Yueqin^1,2  Boons, Geert-Jan³  Wang, Siming^1,2  Wang, Binghe^1,2 

[1] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA

[2] Georgia State Univ, Ctr Diagnost & Therapeut, Atlanta, GA 30302 USA

[3] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

[4] Univ Bordeaux, Inst Europeen Chim & Biol, INCIA, CNRS UMR 5287, 2 Rue Robert Escarpit, F-33607 Pessac, France

关键词: Sodium azide;    Click chemistry;    Fluorescent detection;    Quantitative analysis;   

DOI  :  10.1016/j.bmcl.2016.02.069

来源: Elsevier

【 摘 要 】

Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10 mu M. Published by Elsevier Ltd.

【 授权许可】

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