Repurposing strategies for tropical disease drug discovery

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:26

Article

Klug, Dana M.¹  Gelb, Michael H.²  Pollastri, Michael P.¹ 

[1] Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02215 USA

[2] Univ Washington, Dept Chem, Campus Box 351700, Seattle, WA 98195 USA

关键词: Drug repurposing;    Target repurposing;    Lead repurposing;    Target class repurposing;    Neglected tropical disease;    Tropical disease;    Piggy-back drug discovery;    Drug repositioning;   

DOI  :  10.1016/j.bmcl.2016.03.103

来源: Elsevier

【 摘 要 】

Neglected tropical diseases (NTDs) and other diseases of the developing world, such as malaria, attract research investments that are disproportionately low compared to their impact on human health worldwide. Therefore, pragmatic methods for launching new drug discovery programs have emerged that repurpose existing chemical matter as new drugs or new starting points for optimization. In this Digest we describe applications of different repurposing approaches for NTDs, and provide a means by which these approaches may be differentiated from each other. These include drug repurposing, target repurposing, target class repurposing, and lead repurposing. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free