Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:27

Article

Legentil, Laurent¹  Belaz, Sorya^2,3  Gangneux, Jean-Pierre^2,3  Robert-Gangneux, Florence^2,3  Ferrieres, Vincent¹ 

[1] Ecole Natl Super Chim Rennes, CNRS, UMR 6226, CS 50837, 11 Allee Beaulieu, F-35708 Rennes 7, France

[2] Univ Rennes 1, INSERM U1085, IRSET, Rennes, France

[3] Ctr Hosp Univ Rennes, Serv Parasitol Mycol, Rennes, France

关键词: Carbohydrates;    Galactofuranosides;    Fluorescence;    Leishmania;    Macrophages;   

DOI  :  10.1016/j.bmcl.2016.11.090

来源: Elsevier

【 摘 要 】

Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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