Synthesis and evaluation of a thio analogue of duocarmycin SA

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:19

Article

MacMillan, Karen S.^2,3  Lajiness, James P.^2,3  Cara, Carlota Lopez¹  Romagnoli, Romeo¹  Robertson, William M.^2,3  Hwang, Inkyu^2,3  Baraldi, Pier Giovanni¹  Boger, Dale L.^2,3 

[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

关键词: Duocarmycin SA;    Antitumor agent;   

DOI  :  10.1016/j.bmcl.2009.10.063

来源: Elsevier

【 摘 要 】

The design, synthesis, and preliminary evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]thieno[3,2-e]indol-4-one-6-carboxylate (CTI) derivatives are detailed representing a single atom change (N to S) embedded in the duocarmycin SA alkylation subunit. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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