Native N-glycopeptide thioester synthesis through N→S acyl transfer

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:21

Article

Premdjee, Bhavesh¹  Adams, Anna L.¹  Macmillan, Derek¹ 

[1] UCL, Dept Chem, London WC1H 0AJ, England

关键词: Glycopeptides;    Native chemical ligation;    Peptide thioesters;   

DOI  :  10.1016/j.bmcl.2011.05.059

来源: Elsevier

【 摘 要 】

Peptide thioesters are important tools for the total synthesis of proteins using native chemical ligation (NCL). Preparation of glycopeptide thioesters, that enable the assembly of homogeneously glycosylated proteins, is complicated by the perceived fragile nature of the sugar moiety. Herein, we demonstrate the compatibility of thioester formation via N -> S acyl transfer with native N-glycopeptides and report observations that will aid in their preparation. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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