Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:20

Article

Boger, Dale L.¹ 

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

关键词: Duocarmycins;    DNA alkylating agents;    Antitumor drugs;   

DOI  :  10.1016/j.bmcl.2010.01.145

来源: Elsevier

【 摘 要 】

The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

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