Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:23

Article

Zhou, Longhu^1,2  Amblard, Franck^1,2  Zhang, Hongwang^1,2  McBrayer, Tamara R.³  Detorio, Mervi A.^1,2  Whitaker, Tony³  Coats, Steven J.³  Schinazi, Raymond F.^1,2 

[1] Emory Univ, Sch Med, Ctr AIDS Res, Lab Biochem Pharmacol,Dept Pediat, Decatur, GA 30033 USA

[2] Vet Affairs Med Ctr, Decatur, GA 30033 USA

[3] RFSPharma LLC, Tucker, GA 30084 USA

关键词: HCV;    Antiviral;    Prodrug;    Janus;   

DOI  :  10.1016/j.bmcl.2013.03.077

来源: Elsevier

【 摘 要 】

The synthesis of new ribo and 2'-beta-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells. Published by Elsevier Ltd.

【 授权许可】

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