Chrobisiamone A, a new bischromone from Cassia siamea and a biomimetic transformation of 5-acetonyl-7-hydroxy-2-methylchromone into cassiarin A

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:18

Article

Oshimi, Shiori¹  Tomizawa, Yuichiro¹  Hirasawa, Yusuke¹  Honda, Toshio¹  Ekasari, Wiwied²  Widyawaruyanti, Aty²  Rudyanto, Marcellino²  Indrayanto, Gunawan²  Zaini, Noor Cholies²  Morita, Hiroshi¹ 

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Airlangga Univ, Jalan Dharmawangsa Dalam 60286, Surabaaya, Indonesia

关键词: bischromone;    chrobisiamone A;    antiplasmodial activity;    Cassia siamea;    biomimetic transformation;   

DOI  :  10.1016/j.bmcl.2008.05.041

来源: Elsevier

【 摘 要 】

A new bischromone, chrobisiamone A (1) with an antiplasmodial activity has been isolated from the leaves of Cassia siamea and the structure was elucidated by 2D NMR analysis. Cyclization of 5-acetonyl-7-hydroxy-2-methylchromone (2) in the presence of ammonium acetate resulted in generation of cassiarin A (3) with an unprecedented tricyclic skeleton, supporting a biogenetic pathway proposed for 3. (C) 2008 Elsevier Ltd. All rights reserved.

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