Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:21

Article

Bai, Mingfeng¹  Achilefu, Samuel^1,2 

[1] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

关键词: NIR;    Cyanine dye;    Contrast agent;    Optical imaging;    Dual fluorescence;   

DOI  :  10.1016/j.bmcl.2010.11.024

来源: Elsevier

【 摘 要 】

We developed a series of near infrared (NIR) cyanine dyes to study dichromic fluorescence phenomenon, which provides new protocols for in vivo optical imaging. Preliminary spectroscopic studies show that dichromic fluorescence correlates with structural symmetry. This feature suggests the potential use of dichromic fluorescent molecules to study biological processes that can alter the structural symmetry of the molecular probes. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free