Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:24

Article

Garro Hugo, A.¹  Manzur Jimena, M.²  Ciuffo Gladys, M.³  Tonn Carlos, E.¹  Pungitore Carlos, R.¹ 

[1] Univ Nac San Luis, Fac Qca Bioqca & Fcia, INTEQUI CONICET, RA-5700 San Luis, Argentina

[2] Univ Nac San Luis, Fac Qca Bioqca & Fcia, Area Biol Mol, RA-5700 San Luis, Argentina

[3] IMIBIO CONICET, Inst Multidisciplinario Invest Biol, Buenos Aires, DF, Argentina

关键词: Coumarins;    Reverse transcriptase;    Polymerase;    Molecular target;    Inhibition;   

DOI  :  10.1016/j.bmcl.2013.12.104

来源: Elsevier

【 摘 要 】

Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 mu M, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 mu M, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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