Bidentate iminodiacetate modified dendrimer for bone imaging

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:27

Article

Pes, Lara¹  Kim, Young^1,2  Tung, Ching-Hsuan¹ 

[1] Weill Cornell Med, Mol Imaging Innovat Inst, Dept Radiol, New York, NY 10021 USA

[2] Chonnam Natl Univ, Sch Med, Dept Pathol, 671 Jebongno, Gwangju 501757, South Korea

关键词: Bone;    Fluorescence imaging;    Hydroxyapatite;    Iminodiacetate;    Dendrimer;   

DOI  :  10.1016/j.bmcl.2017.01.059

来源: Elsevier

【 摘 要 】

A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite, calcium oxalate and calcium phosphate salts. In mice, the probe offered vivid skeletal details after intravenous delivery. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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