Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:19

Article

Chiosis, Gabriela¹ 

[1] Mem Sloan Kettering Canc Ctr, Program Mol Pharmacol & Chem, New York, NY 10021 USA

关键词: Hsp90;    Microwave-assisted organic synthesis;    Purines;    Cancer;    Neurodegenerative diseases;   

DOI  :  10.1016/j.bmcl.2008.11.057

来源: Elsevier

【 摘 要 】

Molecular chaperone heat shock protein 90 (Hsp90) is an important target in cancer and neurodegenerative diseases, and has rapidly become the focus of several drug discovery efforts. Among small molecule Hsp90 inhibitors with clinical applicability are derivatives of 8-arylmethyl-9H-purin-6-amine class. Here we report the use of microwave-assisted chemistry for the successful one-pot delivery of 8-arylmethyl-9H-purin-6-amines. We discuss the applicability as well as the limitations of this method towards the creation of a large chemical diversity in the 8-arylmethyl-9H-purin-6-amine series. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

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