Makomotindoline from Makomotake, Zizania latifolia infected with Ustilago esculenta

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:22

Article

Suzuki, Tomohiro²  Choi, Jae-Hoon²  Kawaguchi, Takumi³  Yamashita, Kimiko²  Morita, Akio³  Hirai, Hirofumi³  Nagai, Kaoru⁴  Hirose, Tomoyasu¹  Omura, Satoshi¹  Sunazuka, Toshiaki¹  Kawagishi, Hirokazu^2,3 

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Shizuoka Univ, Grad Sch Sci & Technol, Suruga Ku, Shizuoka 4228529, Japan

[3] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Suruga Ku, Shizuoka 4228529, Japan

[4] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Epigenet Med, Yamanashi 4093898, Japan

关键词: Makomotake;    Ustilago esculenta;    Structure determination;    Glioma cell;    Synthesis;   

DOI  :  10.1016/j.bmcl.2012.05.021

来源: Elsevier

【 摘 要 】

Makomotindoline (1) was isolated from Makomotake, Zizania latifolia infected with Ustilago esculenta. The structure was determined by the interpretation of spectroscopic data and synthesis. Makomotindoline (1), its L-Glc isomer (2) and its aglycon (3) were synthesized and their effects on rat glioma cells showed adverse effects on the cell growth. (C) 2012 Elsevier Ltd. All rights reserved.

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