A one-pot synthesis of α-L-threofuranosyl nucleoside triphosphates (tNTPs)

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:26

Article

Sau, Sujay P.¹  Chaput, John C.¹ 

[1] Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA 92697 USA

关键词: TNA triphosphate;    Phosphoramidite;    One-pot synthesis;    Moisture tolerant;    Thermal stability;   

DOI  :  10.1016/j.bmcl.2016.05.057

来源: Elsevier

【 摘 要 】

TNA (alpha-L-threofuranosyl nucleoside) triphosphates of adenosine (tATP), guanosine (tGTP), cytidine (tCTP), and thymidine (tTTP) were synthesized from their corresponding 3'-O-phosphoramidite derivatives using a novel one-pot reaction that is less moisture sensitive than traditional methods. The chemically synthesized tNTPs, despite containing an unnatural 3'-triphosphate moiety, are similar in thermal stability to natural nucleotide triphosphates. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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