Modulation of mitochondrial dysfunction for treatment of disease

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:29

Review

Webb, Michael¹  Sideris, Dionisia P.¹  Biddle, Margaret¹ 

[1] Mitobridge Inc, 1030 Massachusetts Ave, Cambridge, MA 02138 USA

关键词: Mitochondria;    Energetics;    Dynamics;    ROS;    Biogenesis;   

DOI  :  10.1016/j.bmcl.2019.03.041

来源: Elsevier

【 摘 要 】

Mitochondrial dysfunction is a causative and/or exacerbating feature of many pathologies. We discuss below approaches to modulate mitochondrial dysfunction that involve (1) increasing their energetic efficiency by targeting gene expression regulators such as PPAR or AMPK, (2) using antioxidant compounds to reduce the toxic reactive oxygen species mitochondria produce under stress, or (3) modulating aspects on the innate mitochondrial quality control system. The latter comprise linked processes of biogenesis, dynamic morphological changes, and elimination of defective mitochondria by mitophagy. We discuss representative compounds in all three classes.

【 授权许可】

Free