CLOZAPINE DECREASES ENKEPHALIN MESSENGER-RNA IN RAT STRIATUM

NEUROSCIENCE LETTERS

卷:136

Article

MERCUGLIANO, M ; CHESSELET, MF

关键词: BASAL GANGLIA;    CLOZAPINE;    ENKEPHALIN;    GLOBUS PALLIDUS;    HALOPERIDOL;    INSITU HYBRIDIZATION;    STRIATUM;   

DOI  :  10.1016/0304-3940(92)90635-K

来源: Elsevier

【 摘 要 】

Typical antipsychotic drugs (i.e. haloperidol) induce extrapyramidal movement disorders while 'atypical' antipsychotics (i.e. clozapine)do not. In situ hybridization histochemistry followed by film autoradiography showed that clozapine treatment (20 mg/kg i.p. daily for 28 days) decreased the level of labelling for preproenkephalin mRNA in the striatum of the rat while haloperidol treatment (1 mg/kg i.p. daily for 28 days) resulted in no change compared with controls. The results suggest that these typical and atypical antipsychotic drugs exert differential effects on the enkephalin-containing striatal projection to the globus pallidus, a pathway critical for the expression of extrapyramidal movement disorders.

【 授权许可】

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