Modulatory influence of stimulus parameters on optokinetic head-tracking response

NEUROSCIENCE LETTERS

卷:479

Article

Thomas, Biju B.¹  Shi, Dallas¹  Khine, Kay¹  Kim, Leo A.^1,2  Sadda, Srinivas R.^1,2 

[1] Doheny Eye Inst, Doheny Retina Inst, Los Angeles, CA 90033 USA

[2] Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA

关键词: Retinal degeneration;    Visual behavior;    Optokinetic testing;    S334ter-line-3 rat;    rd10 mice;   

DOI  :  10.1016/j.neulet.2010.05.031

来源: Elsevier

【 摘 要 】

Optokinetic testing is a non-invasive technique, widely used for visual functional evaluation in rodents. The modulatory influence of optokinetic stimulus parameters such as contrast level and grating speed on head-tracking response in normal and retinal degenerate (RD) mice (rd10) and rats (S334ter-line-3) was evaluated using a computer-based testing apparatus. In normal (non-RD) mice and rats, specific stripe width and grating speed was found to evoke maximum optokinetic head-tracking response. In line-3 RD rats, the contrast sensitivity loss was slow and remained close to the baseline (normal control) level until very late in the disease, whereas, in rd10 mice the progression of the contrast sensitivity loss was more rapid. Observed differences between rd10 mice and line-3 RD rats in the progression of contrast sensitivity loss may not be directly related to the degree of photoreceptor loss. In young RD mice, the modulatory influence of stimulus parameters on optokinetic head-tracking response was similar to normal control animals. During later stages, slower grating speed was required to evoke the maximum optokinetic response. Grating speed had lesser apparent influence on the response properties of line-3 RD rats. Discrepancies between the two RD models in the modulatory influence of optokinetic stimulus parameters can be the manifestation of fundamental species differences and/or differences in the degeneration pattern. This study highlights the importance of careful selection of appropriate stimulus parameters for testing optokinetic head-tracking response in RD animals. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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