Study of the origin of short- and long-latency SSEP during recovery from brain ischemia in a rat model

NEUROSCIENCE LETTERS

卷:485

Article

Wu, Dan¹  Anastassios, Bezerianos^1,3  Xiong, Wei²  Madhok, Jai¹  Jia, Xiaofeng^1,4  Thakor, Nitish V.¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

[3] Univ Patras, Sch Med, Dept Med Phys, Patras 26500, Greece

[4] Johns Hopkins Univ, Sch Med, Dept Phys Med & Rehabil, Baltimore, MD 21205 USA

关键词: Somatosensory evoked potential;    Short/long-latency;    Brain ischemia;    Independent component analysis;    Thalamocortical;   

DOI  :  10.1016/j.neulet.2010.08.086

来源: Elsevier

【 摘 要 】

Somatosensory evoked potentials (SSEPs) have been established as an electrophysiological tool for the prognostication of neurological outcome in patients with hypoxic-ischemic brain injury. The early and late responses in SSEPs reflect the sequential activation of neural structures along the somatosensory pathway. This study reports that the SSEP can be separated into early (short-latency, SL) and late (long-latency, LL) responses using independent component analysis (ICA), based on the assumption that these components are generated from different neural sources. Moreover, this source separation into the SL and LL components allows analysis of electrophysiological response to brain injury, even when the SSEPs are severely distorted and SL and LL components get mixed. With the help of ICA decomposition and corrected peak estimation, the latency of LL-SSEP is shown to be predictive of long-term neurological outcome. Further, it is shown that the recovery processes of SL- and LL-SSEPs follow different dynamics, with the SL-SSEP restored earlier than LL-SSEP. We predict that the SL- and LL-SSEPs reflect the timing of the progression of evoked response through the thalamocortical pathway and as such respond differently depending upon injury and recovery of the thalamic and cortical regions, respectively. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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