Targets for preventing epilepsy following cortical injury

NEUROSCIENCE LETTERS

卷:497

Review

Li, Huifang¹  McDonald, Whitney¹  Parada, Isabel¹  Faria, Leonardo¹  Graber, Kevin¹  Takahashi, D. Koji¹  Ma, Yunyong¹  Prince, David¹ 

[1] Stanford Univ, Epilepsy Res Lab, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA 94305 USA

关键词: Epilepsy;    Cortical injury;    Interneurons;    Sprouting;    Prophylaxis;    Posttraumatic;   

DOI  :  10.1016/j.neulet.2011.02.042

来源: Elsevier

【 摘 要 】

Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectivity as prominent targets for prophylactic therapies. Promising laboratory results suggest that it will be possible to experimentally modify these aberrant processes and interfere with epileptogenesis. However, a number of key issues must be addressed before these results can be used to frame clinical antiepileptogenic therapy. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free