Dendritic spine dysgenesis in autism related disorders

NEUROSCIENCE LETTERS

卷:601

Review

Phillips, Mary¹  Pozzo-Miller, Lucas¹ 

[1] Univ Alabama Birmingham, Dept Neurobiol, Civitan Int Res Ctr, Birmingham, AL 35294 USA

关键词: mTOR;    mGluR;    TrkB;    Fragile X;    Rett syndrome;    MeCP2;    Intellectual disability;   

DOI  :  10.1016/j.neulet.2015.01.011

来源: Elsevier

【 摘 要 】

The activity-dependent structural and functional plasticity of dendritic spines has led to the long-standing belief that these neuronal compartments are the subcellular sites of learning and memory. Of relevance to human health, central neurons in several neuropsychiatric illnesses, including autism related disorders, have atypical numbers and morphologies of dendritic spines. These so-called dendritic spine dysgeneses found in individuals with autism related disorders are consistently replicated in experimental mouse models. Dendritic spine dysgenesis reflects the underlying synaptopathology that drives clinically relevant behavioral deficits in experimental mouse models, providing a platform for testing new therapeutic approaches. By examining molecular signaling pathways, synaptic deficits, and spine dysgenesis in experimental mouse models of autism related disorders we find strong evidence for mTOR to be a critical point of convergence and promising therapeutic target. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free