Neural signature of tDCS, tPCS and their combination: Comparing the effects on neural plasticity

NEUROSCIENCE LETTERS

卷:637

Article

Thibaut, Aurore^1,2  Russo, Cristina^1,3,4  Morales-Quezada, Leon¹  Hurtado-Puerto, Aura⁵  Deitos, Alicia^1,6,7  Freedman, Steven⁸  Carvalho, Sandra^1,9  Fregni, Felipe¹ 

[1] Harvard Med Sch, Spaulding Rehabil Hosp, Spaulding Labuschagne Neuromodulat Ctr, Dept Phys Med & Rehabil, Boston, MA USA

[2] Univ & Univ Hosp, GIGA Res, Coma Sci Grp, Liege, Belgium

[3] Univ Milano Bicocca, Dept Psychol, Milan, Italy

[4] Univ Milano Bicocca, Milan Ctr Neurosci NeuroMi, Milan, Italy

[5] Massachusetts Gen Hosp, Dept Psychiat, Transcranial Magnet Stimulat Clin Serv, Lab Neuropsychiat & Neuromodulat, Boston, MA 02114 USA

[6] Univ Fed Rio Grande do Sul, Sch Med, Postgrad Program Med Sci, Porto Alegre, RS, Brazil

[7] Univ Fed Rio Grande do Sul, Lab Pain & Neuromodulat, Porto Alegre, RS, Brazil

[8] Beth Israel Deaconess Med Ctr, Div Translat Res, Boston, MA 02215 USA

[9] Univ Minho, Sch Psychol EPsi, CIPsi, Neuropsychophysiol Lab, Campus Gualtar, P-4710057 Braga, Portugal

关键词: Non-invasive brain stimulation;    tPCS;    tDCS;    EEG;    Top-down/bottom-up connectivity;   

DOI  :  10.1016/j.neulet.2016.10.026

来源: Elsevier

【 摘 要 】

Transcranial pulsed current stimulation (tPCS) and transcranial direct current stimulation (tDCS) are two noninvasive neuromodulatory brain stimulation techniques whose effects on human brain and behavior have been studied individually. In the present study we aimed to quantify the effects of tDCS and tPCS, individually and in combination, on cortical activity, sensitivity and pain-related assessments in healthy individuals in order to understand their neurophysiological mechanisms and potential applications in clinical populations. A total of 48 healthy individuals participated in this randomized double blind sham controlled study. Participants were randomized to receive a single stimulation session of either: active or sham tPCS and active or sham tDCS. Quantitative electroencephalography (qEEG), sensitivity and pain assessments were used before and after each stimulation session. We observed that tPCS had a higher effect on power, as compared to tDCS, in several bandwidths on various cortical regions: the theta band in the parietal region (p = 0.021), the alpha band in the temporal (p=0.009), parietal (p = 0.0063), and occipital (p < 0.0001) regions. We found that the combination of tPCS and tDCS significantly decreased power in the low beta bandwidth of the frontal (p = 0.0006), central (p = 0.0001), and occipital (p = 0.0003) regions, when compared to sham stimulation. Additionally, tDCS significantly increased power in high beta over the temporal (p = 0.0015) and parietal (p = 0.0007) regions, as compared to sham. We found no effect on sensitivity or pain-related assessments. We concluded that tPCS and tDCS have different neurophysiological mechanisms, elicit distinct signatures, and that the combination of the two leads to no effect or a decrease on qEEG power. Further studies are required to examine the effects of these techniques on clinical populations in which EEG signatures have been found altered. (C) 2016 Published by Elsevier Ireland Ltd.

【 授权许可】

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