Cerebellar contribution to absence epilepsy

NEUROSCIENCE LETTERS

卷:761

Review

Akyuz, Enes¹  Ozenen, Cansu²  Pinyazhko, Oleh R.^3,4  Poshyvak, Olesya B.³  Godlevsky, Leonid S.⁵ 

[1] Univ Hlth Sci, Fac Int Med, Dept Biophys, Istanbul, Turkey

[2] Abant Izzet Baysal Univ, Fac Med, Bolu, Turkey

[3] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmacol, Lvov, Ukraine

[4] WSIiZ, Dept Civilizat Dis & Regenerat Med, Rzeszow, Poland

[5] Odesa Natl Med Univ, Dept Biophys Informat & Med Devices, 2,Valikhovsky Lane, UA-65082 Odesa, Ukraine

关键词: Absence epilepsy;    Spike-wave discharges;    Cerebellum;    Deep brain stimulation;    Penicillin induced foci;   

DOI  :  10.1016/j.neulet.2021.136110

来源: Elsevier

【 摘 要 】

The new aggregate data analyses revealed the earlier missing role of cerebellum long-term electrical stimulation in the absence epilepsy. Neurophysiologic data gained by authors favor that cerebellar serial deep brain stimulation (DBS) (100 Hz) causes the transformation of penicillin-induced cortical focal discharges into prolonged 3,5-3,75 sec oscillations resembling spike-wave discharges (SWD) in cats. Such SWDs were not organized in the form of bursts and persisted continuously after stimulation. Therefore, the appearance of prolonged periods of SWD is regarded as a tonic cerebellar influence upon pacemaker of SWD and might be caused by the long-lasting DBS-induced increase of GABA-ergic extrasynaptic inhibition in the forebrain networks. The absence seizure facilitation caused by cerebellar DBS was discussed with the reviewed data on optogenetic stimulation, neuronal activity of cerebellar structures, and imaging data.

【 授权许可】

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