Taste cell formation does not require gustatory and somatosensory innervation

NEUROSCIENCE LETTERS

卷:471

Article

Nosrat, Christopher A.¹ 

[1] Univ Tennessee, Hlth Sci Ctr, Dept Biosci Res, Coll Dent, Memphis, TN 38163 USA

关键词: Gustation;    Neurotrophin;    Development;    Taste buds;    BDNF;    NT-3;   

DOI  :  10.1016/j.neulet.2010.01.039

来源: Elsevier

【 摘 要 】

Dependency of taste buds and taste papillae on innervation has been debated for a long time. Previous research showed neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), play an important role for the establishment of the lingual gustatory and somatosensory innervation. BDNF null mutant mice showed severe deficits in gustatory innervation and loss of taste buds while NT-3 null mutation reduced lingual somatosensory innervation to tongue papillae. These results proved BDNF or NT-3 null mutations affected different sensory modalities (i.e. gustatory and somatosensory, respectively). In this Study, we analyzed taste bud development in BDNF x NT-3 double knockout mice to examine the relationship between taste bud development and gustatory/somatosensory innervation. Our results demonstrate that, at the initial stage, before nerve fibers reached the appropriate areas in the papilla, taste bud formation did not require innervation. However, at the synaptogenic stage, after nerve fibers ramified into the apical epithelium, innervation was required and played an essential role in the development of taste buds/papillae. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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