Endothelin-1-induced priming to capsaicin in young animals

NEUROSCIENCE LETTERS

卷:567

Article

Smith, Terika¹  Beasley, Sarah¹  Smith, Sherika¹  Mark, Isiasha¹  Sweitzer, Sarah M.^1,2 

[1] Univ S Carolina, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29208 USA

[2] Presbyterian Coll Sch Pharm, Dept Pharmaceut & Adm Sci, Clinton, SC USA

关键词: Endothelin-1 (ET-1);    Capsaicin;    Neonatal rat;    Nociception;   

DOI  :  10.1016/j.neulet.2014.03.017

来源: Elsevier

【 摘 要 】

Endothelin-1 (ET-1) is a known algogen that causes acute pain and sensitization in humans and spontaneous nociceptive behaviors when injected into the periphery in rats. This study sought to examine the effect of ET-1 exposure in the neonatal period on subsequent contralateral capsaicin-induced secondary mechanical hyperalgesia. ET-1 or saline was injected into the left plantar hindpaw on postnatal day 7 (P7). On postnatal day 11 (P11), capsaicin cream or control lotion was applied to the right dorsum hind paw and mechanical paw withdrawal thresholds were measured in the plantar hind paw. In saline control males, P11 administration of capsaicin produced a secondary mechanical hyperalgesia that was still present at 2 h. Neonatal priming with ET-1 did not alter the magnitude or the duration of secondary mechanical hyperalgesia in males. In contrast, in control females, P11 administration of capsaicin produced less than 40 min of mechanical hyperalgesia. Neonatal priming with ET-1 prolonged the duration of secondary mechanical hyperalgesia in females. Priming with ET-1 on P7 led to a significant increase in capsaicin-induced Fos expression in the dorsal horn of the spinal cord in both males and females compared to controls (p < 0.001). These findings further suggest that pain in early life may alter future responses to painful stimuli at both the behavioral and neuronal level. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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