Flexible weighting of diverse inputs makes hippocampal function malleable

NEUROSCIENCE LETTERS

卷:680

Review

Aly, Mariam^1,2  Turk-Browne, Nicholas B.^1,3,4 

[1] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA

[2] Columbia Univ, Dept Psychol, 406 Schermerhorn Hall, New York, NY 10027 USA

[3] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA

[4] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

关键词: Episodic memory;    Relational representations;    Pattern separation;    Pattern completion;    Match/mismatch detection;   

DOI  :  10.1016/j.neulet.2017.05.063

来源: Elsevier

【 摘 要 】

Classic theories of hippocampal function have emphasized its role as a dedicated memory system, but recent research has shown that it contributes broadly to many aspects of cognition, including attention and perception. We propose that the reason the hippocampus plays such a broad role in cognition is that its function is particularly malleable. We argue that this malleability arises because the hippocampus receives diverse anatomical inputs and these inputs are flexibly weighted based on behavioral goals. We discuss examples of how hippocampal representations can be flexibly weighted, focusing on hippocampal modulation by attention. Finally, we suggest some general neural mechanisms and core hippocampal computations that may enable the hippocampus to support diverse cognitive functions, including attention, perception, and memory. Together, this work suggests that great progress can and has been made in understanding the hippocampus by considering how the domain-general computations it performs allow it to dynamically contribute to many different behaviors. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free