A left temporal lobe impairment of auditory information processing in schizophrenia: An event-related potential study

NEUROSCIENCE LETTERS

卷:229

Article

Schall, U ; Schon, A ; Zerbin, D ; Bender, S ; Eggers, C ; Oades, RD

关键词: prepulse inhibition;    sensory gating;    P1/P50;    frontal and temporal lobe;    schizophrenia;    lateralization;   

DOI  :  10.1016/S0304-3940(97)00403-5

来源: Elsevier

【 摘 要 】

A measure of auditory prepulse inhibition (PPI) is the reduction of the scalp-recorded P1 event-related potential (ERP) after a sound that is preceded by 100-300 ms by a click as prepulse. This measure of sensory gating was adapted to study the effect of a prepulse on processing tones that were part of a 'go no-go' discrimination. ERPs were recorded at right and left, frontal and temporal sites in groups of patients with schizophrenia (SCH) or obsessive compulsive disorder (OCD) and healthy controls (CON). A prepulse 100 ms but not 500 ms before either tone reduced the Fl ERP amplitude in healthy and OCD subjects but not SCH patients. At frontal and temporal recording sites the Fl amplitude was similar bilaterally in controls but showed a right temporal shift in the SCH patients. If the tone was the 'no-go' tone, the prepulse reduced the N1 amplitude in both the CON and SCH groups. The N1 was similar, bilaterally in controls but again showed a right temporal shift in the SCH group. These results show a reduction of a PPI-like effect on early processing (Pi) that is more marked in the left hemisphere of SCH patients and may affect channel selection for processing information (N1) about task-relevant sounds. (C) 1997 Elsevier Science Ireland Ltd.

【 授权许可】

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