Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla

NEUROSCIENCE LETTERS

卷:617

Article

Leong, Mai Lan^1,2  Speltz, Rebecca^1,3  Wessendorf, Martin¹ 

[1] Univ Minnesota, Dept Neurosci, 6-145 Jackson Hall,321 Church St SE, Minneapolis, MN 55455 USA

[2] OMSIV Des Moines Univ, 3200 Grand Ave, Des Moines, IA 50312 USA

[3] Univ Minnesota, Sch Dent, Dept Diagnost & Biol Sci, 6-145 Jackson Hall,321 Church St SE, Minneapolis, MN 55455 USA

关键词: Pain;    Neuropathy;    Medulla;    Nociception;    Apoptosis;    Glia;   

DOI  :  10.1016/j.neulet.2016.02.006

来源: Elsevier

【 摘 要 】

In previous studies we have reported that spinal nerve ligation (SNL), a model of neuropathic pain, results in the loss of over 20% of neurons in the rostral portion of the ventromedial medulla (RVM) in rats, 10 days after SNL. The RVM is involved in pain modulation and we have proposed that loss of pain inhibition from the RVM, including loss of RVM serotonin neurons, contributes to the increased hypersensitivity observed after SNL. In the present study we examined whether RVM neuronal loss occurs in two other models of neuropathic pain, chronic constriction injury (CCI) and spared nerve injury (SNI). We found no evidence for neuronal loss 10 days after either nerve injury, a time when robust tactile hypersensitivity is present in both CCI and SNI. We conclude that loss of RVM neurons appears not to be required for expression of tactile hypersensitivity in these models of neuropathic pain. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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