Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress

NEUROSCIENCE LETTERS

卷:545

Article

Zhang, Jie^1,2,3  Abdallah, Chadi G.^3,4  Chen, Yaowen⁵  Huang, Tianhua⁶  Huang, Qingjun¹  Xu, Chongtao¹  Xiao, Yeyu²  Liu, Yuzhen⁷  Ding, Yan² 

[1] Shantou Univ, Coll Med, Mental Hlth Ctr, Shantou 515041, Guangdong, Peoples R China

[2] Shantou Univ, Coll Med, Dept Radiol, Affiliated Hosp 2, Shantou 515041, Guangdong, Peoples R China

[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[4] Vet Affairs Connecticut Healthcare Syst, Natl Ctr PTSD, Clin Neurosci Div, New Haven, CT USA

[5] Shantou Univ, Cent Lab, Shantou 515041, Guangdong, Peoples R China

[6] Shantou Univ, Coll Med, Res Ctr Reprod Med, Shantou 515041, Guangdong, Peoples R China

[7] Shantou Univ, Coll Med, Dept ENT, Affiliated Hosp 1, Shantou 515041, Guangdong, Peoples R China

关键词: Early life stress;    Adolescence;    Prefrontal cortex;    Glutamate;    Magnetic resonance spectroscopy;    Rat;   

DOI  :  10.1016/j.neulet.2013.04.035

来源: Elsevier

【 摘 要 】

The present study investigated the effect of early life stress in adolescent rats on brain metabolites, serum corticosterone, and depressive-like behavior. A group of rats was subject to early life stress from postnatal day (PND) 1 to 14. A matched control group was studied. Behavioral tests, serum corticosterone and high-resolution proton magnetic resonance spectroscopy were conducted between PND 30 and 40. In this study, adolescent rats exposed to early life stress demonstrated depressive-like behavior and increased serum corticosterone during adolescence. They also showed reduced glutamate, glutamine, and N-acetylaspartate (NAA) levels in the prefrontal cortex. A reduced myo-inositol level, consistent with astroglial deficits, was observed but was not statistically significant. Together, these findings characterize the effect of early life stress on adolescent animals and underscore the long-lasting and detrimental effects of childhood adversities. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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