期刊论文详细信息
NEUROSCIENCE LETTERS 卷:652
The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms
Review
Geoffroy, Cedric G.1  Meves, Jessica M.1  Zheng, Binhai1 
[1] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA
关键词: Spinal cord injury;    Aging;    Axon growth;    Axon regeneration;    Neuron-intrinsic;    CNS injury;   
DOI  :  10.1016/j.neulet.2016.11.003
来源: Elsevier
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【 摘 要 】

Age is an important consideration for recovery and repair after spinal cord injury. Spinal cord injury is increasingly affecting the middle-aged and aging populations. Despite rapid progress in research to promote axonal regeneration and repair, our understanding of how age can modulate this repair is rather limited. In this review, we discuss the literature supporting the notion of an age-dependent decline in axonal growth after central nervous system (CNS) injury. While both neuron-intrinsic and extrinsic factors are involved in the control of axon growth after injury, here we focus on possible intrinsic mechanisms for this age-dependent decline. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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