Age of onset of marijuana use impacts inhibitory processing

NEUROSCIENCE LETTERS

卷:511

Article

Gruber, Staci A.^1,3  Goenenc, Atilla³  Killgore, William D. S.^2,3 

[1] Harvard Univ, Sch Med, McLean Hosp, Brain Imaging Ctr, Belmont, MA 02478 USA

[2] McLean Hosp, Brain Imaging Ctr, Affect Neurosci Lab, Belmont, MA 02478 USA

[3] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA

关键词: Marijuana;    Cognitive control;    Inhibition;    Age of onset;    FMRI;   

DOI  :  10.1016/j.neulet.2012.01.039

来源: Elsevier

【 摘 要 】

Difficulties in the ability to successfully inhibit impulsive behaviors have been reported in marijuana (MJ) smokers, yet few studies have made direct comparisons between early (prior to age 16) and late (age 16 or later) onset MJ smokers, specifically during behavioral inhibition tasks. The current study utilized the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) in chronic, heavy MJ smokers and healthy non-MJ smoking controls which revealed a more focal pattern of anterior cingulate activity in controls relative to smokers. Early onset smokers had more focal activation but tended to make more errors of commission relative to late onset smokers, suggesting a possible neural adaptation despite difficulty with behavioral inhibition. Further investigation is warranted, as early exposure to MJ may result in reorganization of critical brain regions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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