Amyloid load in nondemented brains correlates with APOE e4

NEUROSCIENCE LETTERS

卷:473

Article

Caselli, Richard J.¹ 

[1] Mayo Clin Arizona, Dept Neurol, Scottsdale, AZ 85259 USA

关键词: Cognitive aging;    Preclinical Alzheimer's disease;    APOE;   

DOI  :  10.1016/j.neulet.2010.02.016

来源: Elsevier

【 摘 要 】

179 cognitively healthy adults enrolled in the Sun Health Brain Donation program between 7/91 and 12/07 were at least 60 years old and nondemented at the time of death (21 had developed mild cognitive impairment [MCI]). Amyloid plaque density, congophilic amyloid angiopathy (CAA), and neurofibrillary tangle (NFT) density scores were based on CERAD criteria and compared in apolipoprotein E (APOE) e4 carriers (n = 42) and noncarriers (NC) (n = 137). Mean age (83.4 +/-.6), gender (45% women), interval between death and brain harvest (3.1 +/- 2.4 h), and brain weight (1200 +/- 119 g) did not differ between e4 carriers (n = 42) and NC. Total plaque density was higher in e4 carriers than NC (6.8 +/- 4.9 vs. 4.3 +/- 4.4, p = .002), and this was true in each of 5 subregions examined. Total CAA (p = .002) and all subregion CAA burden was also higher in e4 carriers. Total neuritic plaque density (1.2 +/- 1.0 vs. 1.0 +/- 1.0, p = .18) and total NET density (3.9 +/- 2.4 vs. 3.6 +/- 2.3, p = .50) did not differ between e4 carriers and NC, nor in any subregion. Eliminating the 21 with MCI did not alter these results. Nondemented APOE e4 carriers over age 60 have a higher burden of total parenchymal and vascular amyloid neuropathology than NC, but no difference in neuritic plaque and NET pathology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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