White matter tractography of the neural network for speech-motor control in children who stutter

NEUROSCIENCE LETTERS

卷:668

Article

Misaghi, Ehsan^1,2  Zhang, Zhaoran³  Gracco, Vincent L.^4,5  De Nil, Luc F.⁶  Beal, Deryk S.^6,7 

[1] Univ Alberta, Fac Med & Dent, Neurosci & Mental Hlth Inst, Edmonton, AB, Canada

[2] Univ Alberta, Fac Rehabil Med, Dept Commun Sci & Disorders, Inst Stuttering Treatment & Res, Edmonton, AB, Canada

[3] Sichuan Univ, Coll Life Sci, Chengdu, Sichuan, Peoples R China

[4] McGill Univ, Sch Commun Sci & Disorders, Montreal, PQ, Canada

[5] Haskins Labs Inc, New Haven, CT USA

[6] Univ Toronto, Fac Med, Dept Speech Language Pathol, Toronto, ON, Canada

[7] Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, 150 Kilgour Rd, Toronto, ON M4G 1R8, Canada

关键词: Diffusion tensor imaging (DTI);    Magnetic resonance imaging (MRI);    Deterministic tractography;    Developmental stuttering;    Speech production;    Motor control;   

DOI  :  10.1016/j.neulet.2018.01.009

来源: Elsevier

【 摘 要 】

Stuttering is a neurodevelopmental speech disorder with a phenotype characterized by speech sound repetitions, prolongations and silent blocks during speech production. Developmental stuttering affects 1% of the population and 5% of children. Neuroanatomical abnormalities in the major white matter tracts, including the arcuate fasciculus, corpus callosum, corticospinal, and frontal aslant tracts (FAT), are associated with the disorder in adults who stutter but are less well studied in children who stutter (CWS). We used deterministic tractography to assess the structural connectivity of the neural network for speech production in CWS and controls. CWS had higher fractional anisotropy and axial diffusivity in the right FAT than controls. Our findings support the involvement of the corticostriatal network early in persistent developmental stuttering.

【 授权许可】

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