Watershed infarcts in a multiple microembolic model of monkey

NEUROSCIENCE LETTERS

卷:499

Article

Maki, Takakuni¹  Wakita, Hideaki²  Mase, Mitsuhito³  Itagaki, Iori⁴  Saito, Naoyuki⁴  Ono, Fumiko⁴  Adachi, Kayo²  Ito, Hidefumi¹  Takahashi, Ryosuke¹  Ihara, Masafumi¹  Tomimoto, Hidekazu⁵ 

[1] Kyoto Univ, Dept Neurol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan

[2] Natl Ctr Geriatr & Gerontol, Dept Vasc Dementia Res, Natl Inst Longev Sci, Tokyo, Japan

[3] Nagoya City Univ, Dept Neurosurg & Restorat Neurosci, Grad Sch Med Sci, Nagoya, Aichi, Japan

[4] Corp Prod & Res Lab Primates, Tsukuba, Ibaraki, Japan

[5] Mie Univ, Dept Neurol, Grad Sch Med, Tsu, Mie, Japan

关键词: Watershed infarct;    Embolic;    Hemodynamic;    Macaque monkey;   

DOI  :  10.1016/j.neulet.2011.05.036

来源: Elsevier

【 摘 要 】

It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50 mu m microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n = 4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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