Association between the superior longitudinal fasciculus and perceptual organization and working memory: A diffusion tensor imaging study

NEUROSCIENCE LETTERS

卷:738

Article

Koshiyama, Daisuke^1,2  Fukunaga, Masaki²  Okada, Naohiro^1,3  Morita, Kentaro¹  Nemoto, Kiyotaka⁴  Yamashita, Fumio⁵  Yamamori, Hidenaga^6,7,8  Yasuda, Yuka^8,9  Matsumoto, Junya⁸  Fujimoto, Michiko⁶  Kudo, Noriko⁸  Azechi, Hirotsugu⁸  Watanabe, Yoshiyuki¹⁰  Kasai, Kiyoto^1,3  Hashimoto, Ryota^6,8,11 

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan

[2] Natl Inst Physiol Sci, Div Cerebral Integrat, Okazaki, Aichi, Japan

[3] Univ Tokyo, Int Res Ctr Neurointelligence WPI IRCN, UTTAS, Tokyo, Japan

[4] Univ Tsukuba, Fac Med, Dept Psychiat, Ibaraki, Japan

[5] Iwate Med Univ, Inst Biomed Sci, Div Ultrahigh Field MRI, Morioka, Iwate, Japan

[6] Osaka Univ, Dept Psychiat, Grad Sch Med, Osaka, Japan

[7] Japan Community Hlth Care Org, Osaka Hosp, Osaka, Japan

[8] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Pathol Mental Dis, Tokyo, Japan

[9] Med Corp Foster, Life Grow Brilliant Mental Clin, Osaka, Japan

[10] Shiga Univ Med Sci, Dept Radiol, Otsu, Shiga, Japan

[11] Osaka Univ, Mol Res Ctr Childrens Mental Dev, United Grad Sch Child Dev, Osaka, Japan

关键词: Superior longitudinal fasciculus;    Diffusion tensor imaging;    Perceptual organization index;    Working memory index;    Magnetic resonance imaging;   

DOI  :  10.1016/j.neulet.2020.135349

来源: Elsevier

【 摘 要 】

The superior longitudinal fasciculus (SLF) is a white matter structure that has long bidirectional projections among the prefrontal, temporal, occipital, and parietal cortices and extends over a wide area in a human brain. Recently, anatomical details of the SLF have been clarified using a diffusion tensor imaging (DTI) template of subjects from the Human Connectome Project. However, the neurobehavioral functions of the SLF have not been fully elucidated. It is speculated that the SLF contributes to a broad cognitive domain including visuospatial nonverbal cognitive ability and verbal memory ability because of its anatomical location; however, previous findings in imaging studies are inconsistent. Showing the contribution of the SLF to cognitive function may be important for improving our understanding of the functional role of white matter structures in the human brain. This study aimed to identify the relationship between DTI indices of the SLF and the Verbal Comprehension, Perceptual Organization, Working Memory and Processing Speed Indices of the Wechsler Adult Intelligence Scale-Third Edition using regression analysis, accounting for the effects of age, sex and scanner type in 583 healthy volunteers. We showed significant correlations between the fractional anisotropy of the left SLF and the Perceptual Organization Index (beta = 0.21, p = 4.5x10(-4)) and Working Memory Index (beta = 0.19, p = 4.0x10(-4)). These findings may have implications for the rehabilitation of cognitive function in patients with neurological disorders.

【 授权许可】

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