MICROGLIAL INTERLEUKIN-1-ALPHA EXPRESSION IN HUMAN HEAD-INJURY - CORRELATIONS WITH NEURONAL AND NEURITIC BETA-AMYLOID PRECURSOR PROTEIN EXPRESSION

NEUROSCIENCE LETTERS

卷:176

Article

GRIFFIN, WST ; SHENG, JG ; GENTLEMAN, SM ; GRAHAM, DI ; MRAK, RE ; ROBERTS, GW

关键词: INTERLEUKIN-1-ALPHA;    BETA-AMYLOID PRECURSOR PROTEIN;    HEAD INJURY;    ALZHEIMERS DISEASE;   

DOI  :  10.1016/0304-3940(94)90066-3

来源: Elsevier

【 摘 要 】

Activated microglia containing IL-1 alpha-immunoreactive (IL-1 alpha(+)) product were increased 3-fold in number in the acute phase following head injury, a risk factor for later development of Alzheimer's disease, and this increase was correlated with a 7-fold increase in the number of neurons with elevated B-amyloid precursor protein (beta-APP) levels (R = 0.78; P < 0.05). Furthermore, clusters of beta-APP(+) dystrophic neurites present in these patients were invariably associated with activated IL-1 alpha(+) microglia. These findings suggest that early overexpression of IL-1 alpha and beta-APP is a priming event for later neuropathological changes evident at end stages of Alzheimer's disease.

【 授权许可】

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