Mini review: Lipids in Peripheral Nerve Disorders

NEUROSCIENCE LETTERS

卷:740

Review

Hornemann, Th.^1,2 

[1] Univ Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland

[2] Univ Zurich, CH-8091 Zurich, Switzerland

关键词: Peripheral neuropathy;    Lipid metabolism;    Hereditary sensory neuropathy type 1;    Sphingolipids;    1-Deoxysphingolipids;    L-Serine;    Diabetic sensory neuropathy;   

DOI  :  10.1016/j.neulet.2020.135455

来源: Elsevier

【 摘 要 】

Neurons are polarized cells whose fundamental functions are to receive, conduct and transmit signals. In bilateral animals, the nervous system is divided into the central (CNS) and peripheral (PNS) nervous system. The main function of the PNS is to connect the CNS to the limbs and organs, essentially serving as a relay between the brain and spinal cord and the rest of the body. Sensory axons can be up to 3 feet in length. Because of its long-reaching and complex structure, the peripheral nervous system (PNS) is exposed and vulnerable to many genetic, metabolic and environmental predispositions. Lipids and lipid intermediates are essential components of nerves. About 50 % of the brain dry weight consist of lipids, which makes it the second highest lipid rich tissue after adipose tissue. However, the role of lipids in neurological disorders in particular of the peripheral nerves is not well understood. This review aims to provide an overview about the role of lipids in the disorders of the PNS.

【 授权许可】

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