The cerebral cortex is a substrate of multiple interactions between GABAergic interneurons and oligodendrocyte lineage cells

NEUROSCIENCE LETTERS

卷:715

Review

Benamer, Najate^1,2  Vidal, Marie^1,2  Angulo, Maria Cecilia^1,2 

[1] Inst Psychiat & Neurosci Paris, INSERM U1266, 102 Rue Sante, F-75014 Paris, France

[2] Univ Paris, Paris, France

关键词: Interneurons;    Oligodendrocyte precursor cells;    Oligodendrocytes;    Myelination;    Parvalbumin;    Synapses;    GABA;    Cortical development;    Medial Ganglionic Eminence (MGE);    Schizophrenia;   

DOI  :  10.1016/j.neulet.2019.134615

来源: Elsevier

【 摘 要 】

In the cerebral cortex, GABAergic interneurons and oligodendrocyte lineage cells share different characteristics and interact despite being neurons and glial cells, respectively. These two distinct cell types share common embryonic origins and are born from precursors expressing similar transcription factors. Moreover, they highly interact with each other through different communication mechanisms during development. Notably, cortical oligodendrocyte precursor cells (OPCs) receive a major and transient GABAergic synaptic input, preferentially from parvalbumin-expressing interneurons, a specific interneuron subtype recently recognized as highly myelinated. In this review, we highlight the similarities and interactions between GABAergic intemeurons and oligodendrocyte lineage cells in the cerebral cortex and suggest potential roles of this intimate interneurono-ligodendroglia relationship in cortical construction. We also propose new lines of research to understand the role of the close link between interneurons and oligodendroglia during cortical development and in pathological conditions such as schizophrenia.

【 授权许可】

Free