Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: A preliminary study

NEUROSCIENCE LETTERS

卷:514

Article

Holsen, Laura M.^2,3  Lee, Jong-Hwan⁴  Spaeth, Sarah B.²  Ogden, Lauren A.²  Klibanski, Anne^3,5  Whitfield-Gabrieli, Susan^6,7  Sloan, Richard P.^8,9  Goldstein, Jill M.^1,2,3,7 

[1] Brigham & Womens Hosp, OBC, Dept Psychiat, Boston, MA 02120 USA

[2] Dept Med, Div Womens Hlth, Boston, MA 02120 USA

[3] Harvard Univ, Sch Med, Boston, MA 02120 USA

[4] Korea Univ, Dept Brain & Cognit Engn, Seoul 136701, South Korea

[5] Massachusetts Gen Hosp, Dept Med, Neuroendocrine Unit, Boston, MA 02114 USA

[6] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[7] MGH & MIT Athinoula Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[8] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY 10032 USA

[9] New York State Psychiat Inst & Hosp, Div Behav Med, New York, NY 10032 USA

关键词: Mood disorders;    Autonomic nervous system;    Sympathovagal balance;    HPG-axis;    Estrogen;    Progesterone;   

DOI  :  10.1016/j.neulet.2012.02.056

来源: Elsevier

【 摘 要 】

The comorbidity of major depressive disorder (MDD) and cardiovascular disease (CVD) is among the 10th leading cause of morbidity and mortality worldwide. Thus, understanding the co-occurrence of these disorders will have major public health significance. MDD is associated with an abnormal stress response, manifested in brain circuitry deficits, gonadal dysfunction, and autonomic nervous system CANS) dysregulation. Contribution of the relationships between these systems to the pathophysiology of MDD is not well understood. The objective of this preliminary study was to investigate, in parallel, relationships between HPG-axis functioning, stress response circuitry activation, and parasympathetic reactivity in healthy controls and women with MOD. Using fMRI with pulse oximetry [from which we calculated the high frequency (HF) component of R-R interval variability (HF-RRV), a measure of parasympathetic modulation] and hormone data, we studied eight women with recurrent MDD in remission and six controls during a stress response paradigm. We demonstrated that hypoactivations of hypothalamus, amygdala, hippocampus, anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and subgenual ACC were associated with lower parasympathetic cardiac modulation in MDD women. Estradiol and progesterone attenuated group differences in the effect of HF-RRV on hypoactivation in the amygdala, hippocampus, ACC, and OFC in MDD women. Findings have implications for understanding the relationship between mood, arousal, heart regulation, and gonadal hormones, and may provide insights into MOD and CVD risk comorbidity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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