Altered GABAA receptor expression during epileptogenesis

NEUROSCIENCE LETTERS

卷:497

Review

Gonzalez, Marco I.¹  Brooks-Kayal, Amy^1,2 

[1] Univ Colorado Denver, Sch Med, Div Neurol, Dept Pediat, Aurora, CO 80045 USA

[2] Childrens Hosp, Aurora, CO 80045 USA

关键词: GABA receptors;    Epileptogenesis;    Epilepsy;    Receptor expression;    Transcriptional regulation;   

DOI  :  10.1016/j.neulet.2011.02.052

来源: Elsevier

【 摘 要 】

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. GABA(A) receptors are heteropentamers formed by assembly of multiple subunits that generate a wide array of receptors with particular distribution and pharmacological profiles. Malfunction of these receptors has been associated with the pathophysiology of epilepsy and contribute to an imbalance of excitatory and inhibitory neurotransmission. The process of epilepsy development (epileptogenesis) is associated with changes in the expression and function of a large number of gene products. One of the major challenges is to effectively determine which changes directly contribute to epilepsy development versus those that are compensatory or not involved in the pathology. Substantial evidence suggests that changes in the expression and function of GABA(A) receptors are involved in the pathogenesis of epilepsy. Identification of the mechanisms involved in GABA(A) receptor malfunction during epileptogenesis and the ability to reverse this malfunction are crucial steps towards definitively answering this question and developing specific and effective therapies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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