SEROTONERGIC EXCITATORY DRIVE TO HYPOGLOSSAL MOTONEURONS IN THE DECEREBRATE CAT

NEUROSCIENCE LETTERS

卷:139

Article

KUBIN, L ; TOJIMA, H ; DAVIES, RO ; PACK, AI

关键词: SEROTONIN;    HYPOGLOSSAL MOTONEURON;    GENIOGLOSSAL MOTONEURON;    DECEREBRATE CAT;    SLEEP APNEA;    RESPIRATION;    UPPER AIRWAY;    MICROINJECTION;   

DOI  :  10.1016/0304-3940(92)90563-M

来源: Elsevier

【 摘 要 】

In decerebrate, paralyzed, vagotomized and artificially ventilated cats, serotonin (5-HT) and its analogues, microinjected into the hypoglossal (XII) motor nucleus, altered the activity of the genioglossal branch of XII nerve. 5-HT, carboxamidotryptamine maleate (5-CT) and DOI (1-5 mM) increased the activity by over 200%. Methysergide reversed this increase. Methysergide, mianserin, or ketanserin (100-250 nl, 1 mM) reduced the spontaneous hypoglossal activity by 20-50%. Buspirone, 8-OH-DPAT and (-)-propranolol were without effect. Thus, 5-HT provides a substantial tonic excitatory drive to XII motoneurons. The 5-HT receptors involved are likely to be type 1C or 2, but uncertainty regarding the affinity profiles of the drugs used in in vivo conditions in the cat precludes a definite identification.

【 授权许可】

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