Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice

NEUROSCIENCE LETTERS

卷:488

Article

Xu, Lijun¹  Xiong, Xiaoxing¹  Ouyang, Yibing¹  Barreto, George¹  Giffard, Rona¹ 

[1] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA

关键词: Hsp72;    Focal ischemia;    Long term;    Behavior;    Rotarod;   

DOI  :  10.1016/j.neulet.2010.11.047

来源: Elsevier

【 摘 要 】

Many brain protective strategies have been tested over short survival intervals, but few have been examined for long term benefit. The inducible member of the Heat shock protein 70 (Hsp70) family, Heat shock protein 72 (Hsp72), has been widely found to reduce ischemic injury. Here we assessed outcome in Hsp72 transgenic overexpressing mice and wild type littermates for one month following transient focal ischemia. Hsp72 reduced infarct area lost and improved behavioral outcome on rotarod and foot fault at one month. Thus protection by Hsp72 overexpression is long lasting, and includes improved recovery of motor function over one month. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free