Mesocorticolimbic monoamines in a rodent model of chronic neuropathic pain

NEUROSCIENCE LETTERS

卷:737

Article

Cunha, Ana Margarida^1,2  Guimaraes, Marco Rafael^1,2  Kokras, Nikolaos^3,4  Sotiropoulos, Ioannis^1,2  Sousa, Nuno^1,2  Almeida, Armando^1,2  Dalla, Christina³  Leite-Almeida, Hugo^1,2 

[1] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal

[2] ICVS 3Bs PT Govt Associate Lab, Braga, Guimaraes, Portugal

[3] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pharmacol, Athens, Greece

[4] Natl & Kapodistrian Univ Athens, Eginit Hosp, Dept Psychiat 1, Athens, Greece

关键词: Dopamine;    Serotonin;    Noradrenaline;    Neuropathy;    Striatum;    Laterality;   

DOI  :  10.1016/j.neulet.2020.135309

来源: Elsevier

【 摘 要 】

Chronic pain manifests in multiple disorders and is highly debilitating. While its pathophysiology is not fully understood, the involvement of the mesocorticolimbic monoaminergic systems have been shown to play a critical role in chronic pain emergence and/or maintenance. In this study, we analyzed the levels of monoamines dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in mesocorticolimbic areas - medial prefrontal cortex, orbitofrontal cortex, striatum, nucleus accumbens and amygdala - 1 month after a neuropathic lesion, Spared Nerve Injury (SNI). In SNI animals, were observed a marginal decrease of DA and 5-HT in the striatum and a rightward shift in the levels of NA in the nucleus accumbens. While mesocorticolimbic monoamines might be relevant for chronic pain pathophysiology its content appears to be relatively unaffected in our experimental conditions.

【 授权许可】

Free