Increased plasma levels of brain-derived neurotrophic factor in patients with long-term bipolar disorder

NEUROSCIENCE LETTERS

卷:475

Article

Barbosa, Izabela Guimaraes^2,3,4  Huguet, Rodrigo Barreto^2,3  Mendonca, Vanessa Amaral⁴  Neves, Fernando Silva⁵  Reis, Helton Jose^2,6  Bauer, Moises Evandro⁷  Janka, Zoltan⁸  Palotas, Andras¹  Teixeira, Antonio Lucio^2,4,9 

[1] Asklepios Med Private Practice & Res Ctr, H-6722 Szeged, Hungary

[2] Univ Fed Minas Gerais, Programa Neurociencias, BR-31270901 Belo Horizonte, MG, Brazil

[3] Inst Previdencia Servidores Minas Gerais IPSEMG, Hosp Governador Israel Pinheiro, Serv Psiquiatria, BR-30130110 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Immunofarmacol, BR-31270901 Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Fac Med, Dept Saude Mental, BR-30130100 Belo Horizonte, MG, Brazil

[6] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, Lab Neurofarmacol, BR-31270901 Belo Horizonte, MG, Brazil

[7] Pontificia Univ Catolica Rio Grande do Sul, Inst Pesquisas Biomed, Lab Imunol Mol & Celular, BR-90610000 Porto Alegre, RS, Brazil

[8] Univ Szeged, Fac Med, Albert Szent Gyorgyi Clin Ctr, Dept Psychiat, H-6725 Szeged, Hungary

[9] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, BR-30130100 Belo Horizonte, MG, Brazil

关键词: Bipolar disorder;    Brain-derived neurotrophic factor;    Mania;    Neurotrophins;   

DOI  :  10.1016/j.neulet.2010.03.055

来源: Elsevier

【 摘 要 】

Recent data indicate that neurotrophins may play a role in the physiopathology of bipolar disorder (BD) and may be useful as biomarkers of the disease. The aim of this study was to evaluate the plasma concentrations of brain-derived neurotrophic factor (BDNF) in BD patients, and to correlate their levels with clinical parameters. BDNF was measured in plasma from 53 BD type I subjects (34 during mania and 19 during euthymia) and 38 healthy controls by enzyme-linked immuno-sorbent assay (ELISA). Patients were assessed by a structured clinical interview (Mini-plus), Young mania and Hamilton depression rating scales. Plasma BDNF levels were significantly increased in patients with mania (P <= 0.001) and euthymia (P <= 0.001) when compared with controls, but did not correlate with any clinical parameters. BDNF concentration was higher in BD patients with 10 or more years of disease. BDNF plasma levels were increased in BD patients, mainly in those with a longer course of disease. In line with previous studies, it is conceivable that BDNF may play a role in the pathophysiology of BD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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