Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice

NEUROSCIENCE LETTERS

卷:579

Article

Berro, L. F.¹  Santos, R.²  Hollais, A. W.²  Wuo-Silva, R.²  Fukushiro, D. F.²  Mari-Kawamoto, E.²  Costa, J. M.²  Trombin, T. F.²  Patti, C. L.²  Grapiglia, S. B.²  Tufik, S.¹  Andersen, M. L.¹  Frussa-Filho, R.^1,2 

[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, BR-04021002 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, Brazil

关键词: Cocaine;    Sleep deprivation;    Hyperlocomotion;    Open field;    Impulsivity;   

DOI  :  10.1016/j.neulet.2014.07.028

来源: Elsevier

【 摘 要 】

Sleep deprivation is common place in modern society. Nowadays, people tend to self-impose less sleep in order to achieve professional or social goals. In the social context, late-night parties are frequently associated with higher availability of recreational drugs with abuse potential. Physiologically, all of these drugs induce an increase in dopamine release in the mesolimbic dopaminergic system, which leads to hyperlocomotion in rodents. Sleep deprivation also seems to play an important role in the events related to the neurotransmission of the dopaminergic system by potentiating its behavioral effects. In this scenario, the aim of the present study was to investigate the effects of total sleep deprivation (6 h) on the acute cocaine-induced locomotor stimulation in male mice. Animals were sleep deprived or maintained in their home cages and subsequently treated with an acute i.p. injection of 15 mg/kg cocaine or saline and observed in the open field. Total sleep deprivation for 6 h potentiated the hyperlocomotion induced by acute cocaine administration. In addition, the cocaine sleep deprived group showed a decreased ratio central/total locomotion compared to the cocaine control group, which might be related to an increase in the impulsiveness of mice. Our data indicate that acute periods of sleep loss should be considered risk factors for cocaine abuse. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free