Ketamine modulates aggressive behavior in adult zebrafish

NEUROSCIENCE LETTERS

卷:684

Article

Michelotti, Paula^1,2  Quadros, Vanessa A.^1,2  Pereira, Maria E.²  Rosemberg, Denis B.^1,2,3 

[1] Univ Fed Santa Maria, Nat & Exact Sci Ctr, Dept Biochem & Mol Biol, Lab Expt Neuropsychobiol, 1000 Roraima Ave, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, Grad Program Biol Sci Toxicol Biochem, 1000 Roraima Ave, BR-97105900 Santa Maria, RS, Brazil

[3] Int Zebrafish Neurosci Res Consortium ZNRC, 309 Palmer Court, Slidell, LA 70458 USA

关键词: Aggressive behavior;    Psychotomimetic drugs;    Stereotypic behaviors;    Ketamine;    Zebrafish;   

DOI  :  10.1016/j.neulet.2018.08.009

来源: Elsevier

【 摘 要 】

Ketamine is a non-competitive glutamatergic antagonist that induces analgesia and anesthesia. Although ketamine displays anxiolytic and antidepressant properties, it may induce pro-psychosis and hallucinogen effects, as well as stereotypic behaviors following acute administration at sub-anesthetic doses. Since heightened aggression is maladaptive and may comorbid with various neuropsychiatric disorders, we aimed to investigate whether ketamine modulates aggressive behavior in adult zebrafish. Fish were acutely exposed to 2, 20, and 40 mg/L ketamine for 20 min and their locomotion, exploratory activity, and aggression towards mirror were further assessed. Ketamine (2 mg/L) increased aggression-related phenotypes, while 20 and 40 mg/L reduced aggression and elicited stereotypic behaviors by causing hyperlocomotion, altering motor patterns, and increasing circling behavior at the higher concentration tested. Collectively, our data expand the utility of zebrafish models to investigate the influence of sub-anesthetic concentrations of ketamine on aggression behavior domain in translational neuropsychiatric research field.

【 授权许可】

Free