Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination

NEUROSCIENCE LETTERS

卷:730

Article

Gamboa, Olga Lucia¹  Brito, Alexandra¹  Abzug, Zachary²  D'Arbeloff, Tracy^1,3  Beynel, Lysianne¹  Wing, Erik A.³  Dannhauer, Moritz¹  Palmer, Hannah¹  Hilbig, Susan A.¹  Crowell, Courtney A.¹  Liu, Sicong¹  Donaldson, Rachel¹  Cabeza, Roberto^3,4  Davis, Simon W.^4,5  Peterchev, Angel, V^1,2,6,7  Sommer, Marc A.^2,3,4,8  Appelbaum, Lawrence G.^1,4 

[1] Duke Univ, Dept Psychiat & Behav Sci, Sch Med, Durham, NC 27706 USA

[2] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA

[3] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27706 USA

[4] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27706 USA

[5] Duke Univ, Dept Neurol, Sch Med, Durham, NC 27706 USA

[6] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27706 USA

[7] Duke Univ, Dept Neurosurg, Sch Med, Durham, NC 27706 USA

[8] Duke Univ, Dept Neurobiol, Sch Med, Durham, NC 27706 USA

关键词: Transcranial Magnetic Stimulation;    Visual Motion;    Paired Pulse TMS;    Motion Sensitive Cortex;    hMT;   

DOI  :  10.1016/j.neulet.2020.135022

来源: Elsevier

【 摘 要 】

The perception of visual motion is dependent on a set of occipitotemporal regions that are readily accessible to neuromodulation. The current study tested if paired-pulse Transcranial Magnetic Stimulation (ppTMS) could modulate motion perception by stimulating the occipital cortex as participants viewed near-threshold motion dot stimuli. In this sham-controlled study, fifteen subjects completed two sessions. On the first visit, resting motor threshold (RMT) was assessed, and participants performed an adaptive direction discrimination task to determine individual motion sensitivity. During the second visit, subjects performed the task with three difficulty levels as TMS pulses were delivered 150 and 50 ms prior to motion stimulus onset at 120% RMT, under the logic that the cumulative inhibitory effect of these pulses would alter motion sensitivity. ppTMS was delivered at one of two locations: 3 cm dorsal and 5 cm lateral to inion (scalp-based coordinate), or at the site of peak activation for motion according to the NeuroSynth fMRI database (meta-analytic coordinate). Sham stimulation was delivered on one-third of trials by tilting the coil 90 degrees. Analyses showed no significant active-versus-sham effects of ppTMS when stimulation was delivered to the meta-analytic (p = 0.15) or scalp-based coordinates (p = 0.17), which were separated by 29 mm on average. Active-versus-sham stimulation differences did not interact with either stimulation location (p = 0.12) or difficulty (p = 0.33). These findings fail to support the hypothesis that long-interval ppTMS recruits inhibitory processes in motion-sensitive cortex but must be considered within the limited parameters used in this design.

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